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- Title
Memory T<sub>H</sub>2 cells induce alternatively activated macrophages to mediate protection against nematode parasites.
- Authors
Anthony, Robert M.; Urban Jr., Joseph F.; Alem, Farhang; Hamed, Hossein A.; Rozo, Cristina T.; Boucher, Jean-Luc; Van Rooijen, Nico; Gause, William C.
- Abstract
Although primary and memory responses against bacteria and viruses have been studied extensively, T helper type 2 (TH2) effector mechanisms leading to host protection against helminthic parasites remain elusive. Examination of the intestinal epithelial submucosa of mice after primary and secondary infections by a natural gastrointestinal parasite revealed a distinct immune-cell infiltrate after challenge, featuring interleukin-4–expressing memory CD4+ T cells that induced IL-4 receptorhi (IL-4Rhi) CD206+ alternatively activated macrophages. In turn, these alternatively activated macrophages (AAMacs) functioned as important effector cells of the protective memory response contributing to parasite elimination, demonstrating a previously unknown mechanism for host protection against intestinal helminths.
- Publication
Nature Medicine, 2006, Vol 12, Issue 8, p955
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm1451