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- Title
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
- Authors
Cardona, Kenneth; Korbutt, Gregory S; Milas, Zvonimir; Lyon, James; Cano, Jose; Jiang, Wanhong; Bello-Laborn, Hameeda; Hacquoil, Brad; Strobert, Elizabeth; Gangappa, Shivaprakash; Weber, Collin J; Pearson, Thomas C; Rajotte, Ray V; Larsen, Christian P
- Abstract
We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.
- Publication
Nature medicine, 2006, Vol 12, Issue 3, p304
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm1375