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- Title
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates.
- Authors
Hering, Bernhard J; Wijkstrom, Martin; Graham, Melanie L; Hårdstedt, Maria; Aasheim, Tor C; Jie, Tun; Ansite, Jeffrey D; Nakano, Masahiko; Cheng, Jane; Li, Wei; Moran, Kathleen; Christians, Uwe; Finnegan, Colleen; Mills, Charles D; Sutherland, David E; Bansal-Pakala, Pratima; Murtaugh, Michael P; Kirchhof, Nicole; Schuurman, Henk-Jan
- Abstract
Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without Gal-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-Gal pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.
- Publication
Nature medicine, 2006, Vol 12, Issue 3, p301
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm1369