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- Title
β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.
- Authors
Frigerio, Simona; Junt, Tobias; Lu, Bao; Gerard, Craig; Zumsteg, Urs; Holländer, Georg A.; Piali, Luca
- Abstract
T cell–mediated loss of insulin-secreting β cells in the islets of Langerhans is the hallmark of type 1 diabetes. The molecular basis for the directed migration of autoreactive T cells leading to insulitis is presently unknown. Here we demonstrate that in response to inflammation, β cells secrete the chemokines CXC ligand 10 and CXC ligand 9, which specifically attract T-effector cells via the CXC chemokine receptor 3. In mice deficient for this receptor, the onset of type 1 diabetes is substantially delayed. Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes.
- Publication
Nature Medicine, 2002, Vol 8, Issue 12, p1414
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm1202-792