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- Title
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.
- Authors
Lu Chen; Hamrah, Pedram; Cursiefen, Claus; Qiang Zhang; Pytowski, Bronislaw; Streilein, J. Wayne; Dana, M. Reza
- Abstract
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
- Publication
Nature Medicine, 2004, Vol 10, Issue 8, p813
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm1078