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- Title
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease.
- Authors
Torres, Vicente E; Wang, Xiaofang; Qian, Qi; Somlo, Stefan; Harris, Peter C; Gattone, Vincent H, 2nd
- Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. The vasopressin V2 receptor (VPV2R) antagonist OPC31260 has been effective in two animal models of PKD with pathologies that are probably related. Here we show, in a mouse model of ADPKD (Pkd2(-/tm1Som)), a similar cellular phenotype and response to OPC31260 treatment, with reduction of renal cyclic AMP (cAMP) levels, prevention of renal enlargement, marked inhibition of cystogenesis and protection of renal function.
- Publication
Nature medicine, 2004, Vol 10, Issue 4, p363
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm1004