We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model.
- Authors
Bolay, Hayrunnisa; Reuter, Uwe; Dunn, Andrew K; Huang, Zhihong; Boas, David A; Moskowitz, Michael A
- Abstract
Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms remain controversial and poorly understood. Here we establish a link between migraine aura and headache by demonstrating that cortical spreading depression, implicated in migraine visual aura, activates trigeminovascular afferents and evokes a series of cortical meningeal and brainstem events consistent with the development of headache. Cortical spreading depression caused long-lasting blood-flow enhancement selectively within the middle meningeal artery dependent upon trigeminal and parasympathetic activation, and plasma protein leakage within the dura mater in part by a neurokinin-1-receptor mechanism. Our findings provide a neural mechanism by which extracerebral cephalic blood flow couples to brain events; this mechanism explains vasodilation during headache and links intense neurometabolic brain activity with the transmission of headache pain by the trigeminal nerve.
- Publication
Nature medicine, 2002, Vol 8, Issue 2, p136
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm0202-136