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- Title
Adoptive transfer of costimulated CD4<sup>+</sup> T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.
- Authors
Levine, Bruce L.; Bernstein, Wendy B.; Aronson, Naomi E.; Schlienger, Katia; Cotte, Julio; Perfetto, Steven; Humphries, Mary J.; Ratto-Kim, Silvia; Birx, Deborah L.; Steffens, Carolyn; Landay, Alan; Carroll, Richard G.; June, Carl H.
- Abstract
To study the safety and feasibility of T-cell reconstitution in HIV-infected individuals, we adoptively transferred activated autologous CD4+ T cells. Polyclonal peripheral blood CD4+ cells were costimulated ex vivo and subjects were given infusions of up to 3 × 1010 activated CD4+ cells. Dose-dependent increases in CD4+ cell counts and in the CD4:CD8 ratio were observed. Sustained increases in the fraction of cytokine-secreting T cells and decreases in the percentage of CD4+CCR5+ cells were noted in vivo, suggesting enhanced function and resistance to HIV infection. The frequency of CD4+Ki-67+ cells increased whereas CD4+ T cells containing T cell?receptor rearrangement excision circles (TRECs) decreased. These findings indicate that expansion of the peripheral T-cell pool mediated the increase in CD4 counts and suggest that approaches to reconstitute CD4 helper cell activity and decrease CCR5 expression may augment natural immunity to HIV infection.
- Publication
Nature Medicine, 2002, Vol 8, Issue 1, p47
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm0102-47