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- Title
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results.
- Authors
van Dam, Gooitzen M; Themelis, George; Crane, Lucia M A; Harlaar, Niels J; Pleijhuis, Rick G; Kelder, Wendy; Sarantopoulos, Athanasios; de Jong, Johannes S; Arts, Henriette J G; van der Zee, Ate G J; Bart, Joost; Low, Philip S; Ntziachristos, Vasilis
- Abstract
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
- Publication
Nature medicine, 2011, Vol 17, Issue 10, p1315
- ISSN
1546-170X
- Publication type
Journal Article
- DOI
10.1038/nm.2472