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- Title
Identification of T helper type 1-like, Foxp3<sup>+</sup> regulatory T cells in human autoimmune disease.
- Authors
Dominguez-Villar, Margarita; Baecher-Allan, Clare M.; Hafler, David A
- Abstract
CD4+CD25highCD127low/- forkhead box p3 (Foxp3)+ regulatory T cells (Treg cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (TH1)-like, interferon-γ (IFN-γ)-secreting Foxp3+ T cells in untreated subjects with relapsing remitting multiple sclerosis (RRMS) as compared to healthy control individuals. In subjects treated with IFN-β, the frequency of IFN-γ+Foxp3+ T cells is similar to that in healthy control subjects. In vitro, human Treg cells from healthy subjects acquire a TH1-like phenotype when cultured in the presence of interleukin-12 (IL-12). TH1-like Treg cells show reduced suppressive activity in vitro, which can partially be reversed by IFN-γ-specific antibodies or by removal of IL-12.
- Publication
Nature Medicine, 2011, Vol 17, Issue 6, p673
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm.2389