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- Title
Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans.
- Authors
Tracey, Irene
- Abstract
The perception of pain is subject to powerful influences. Understanding how these are mediated at a neuroanatomical and neurobiological level provides us with valuable information that has a direct impact on our ability to harness positive and minimize negative effects therapeutically, as well as optimize clinical trial designs when developing new analgesics. This is particularly relevant for placebo and nocebo effects. New research findings have directly contributed to an increased understanding of how placebo and nocebo effects are produced and what biological and psychological factors influence variances in the magnitude of the effect. The findings have relevance for chronic pain states and other disorders, where abnormal functioning of crucial brain regions might affect analgesic outcome even in the normal therapeutic setting.
- Publication
Nature medicine, 2010, Vol 16, Issue 11, p1277
- ISSN
1546-170X
- Publication type
Journal Article
- DOI
10.1038/nm.2229