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- Title
Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.
- Authors
Sarasin-Filipowicz, Magdalena; Krol, Jacek; Markiewicz, Ilona; Heim, Markus H; Filipowicz, Witold
- Abstract
Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.
- Publication
Nature medicine, 2009, Vol 15, Issue 1, p31
- ISSN
1546-170X
- Publication type
Journal Article
- DOI
10.1038/nm.1902