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- Title
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
- Authors
Suh, Woong-Kyung; Gajewska, Beata U; Okada, Hitoshi; Gronski, Matthew A; Bertram, Edward M; Dawicki, Wojciech; Duncan, Gordon S; Bukczynski, Jacob; Plyte, Suzanne; Elia, Andrew; Wakeham, Andrew; Itie, Annick; Chung, Stephen; Da Costa, Joan; Arya, Sudha; Horan, Tom; Campbell, Pauline; Gaida, Kevin; Ohashi, Pamela S; Watts, Tania H; Yoshinaga, Steven K; Bray, Mark R; Jordana, Manel; Mak, Tak W
- Abstract
We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3-deficient mice developed more severe airway inflammation than did wild-type mice in conditions in which T helper cells differentiated toward type 1 (T(H)1) rather than type 2 (T(H)2). B7-H3 expression was consistently enhanced by interferon-gamma but suppressed by interleukin 4 in dendritic cells. B7-H3-deficient mice developed experimental autoimmune encephalomyelitis several days earlier than their wild-type littermates, and accumulated higher concentrations of autoantibodies to DNA. Thus, B7-H3 is a negative regulator that preferentially affects T(H)1 responses.
- Publication
Nature immunology, 2003, Vol 4, Issue 9, p899
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni967