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- Title
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
- Authors
Fitzgerald, Katherine A; McWhirter, Sarah M; Faia, Kerrie L; Rowe, Daniel C; Latz, Eicke; Golenbock, Douglas T; Coyle, Anthony J; Liao, Sha-Mei; Maniatis, Tom
- Abstract
The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activation of IRF3 and NF-kappaB. Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IkappaB kinase homologs, IkappaB kinase-epsilon (IKKepsilon) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-kappaB activation, are also essential components of the IRF3 signaling pathway. Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response.
- Publication
Nature immunology, 2003, Vol 4, Issue 5, p491
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni921