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- Title
Monoallelic expression of the murine gene encoding Toll-like receptor 4.
- Authors
Pereira, João Pedro; Girard, Robert; Chaby, Richard; Cumano, Ana; Vieira, Paulo
- Abstract
Defects in the gene encoding Toll-like receptor 4 (Tlr4) result in impaired responses to lipopolysaccharide (LPS), rendering mice sensitive to infections by Gram-negative bacteria. C3H/HeJ mice have a codominant allele with a mutation in Tlr4, which results in an intermediate response to LPS in F1 mice from crosses of responder and C3H/HeJ mice. Here we show that this intermediate response to LPS is due to monoallelic expression of Tlr4. Allele usage is maintained during clonal expansion, a situation that resembles allelic exclusion. In contrast, Tlr4 is deleted on the recessive C57BL/10ScCr allele and all cells from F1 mice from crosses of responder and C57BL/10ScCr mice express TLR4 protein. Thus, Tlr4 is an autosomal gene whose expression is regulated similarly to that of genes on the X chromosome.
- Publication
Nature immunology, 2003, Vol 4, Issue 5, p464
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni917