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- Title
An essential role for Scurfin in CD4<sup>+</sup>CD25<sup>+</sup> T regulatory cells.
- Authors
Khattri, Roli; Cox, Tom; Yasayko, Sue-Ann; Ramsdell, Fred
- Abstract
The molecular properties that characterize CD4[SUP+]CD25[SUP+] regulatory T cells (T[SUBR] cells) remain elusive. Absence of the transcription factor Scurfin (also known as forkhead box P3 and encoded by Foxp3) causes a rapidly fatal lymphoproliferative disease, similar to that seen in mice Jacking cytolytic T lymphocyte-associated antigen 4 (CTLA-4). Here we show that Foxp3 is highly expressed by T[SUBR] cells and is associated with T[SUBR] cell activity and phenotype. Scurfin-deficient mice lack T[SUBR] cells, whereas mice that overexpress Foxp3 possess more T[SUBR] cells. In Foxp3-overexpressing mice, both CD4[SUP+]CD25[SUP-] and CD4[SUP-]CD8[SUP+] T cells show suppressive activity and CD4[SUP+]CD25[SUP-] cells express glucocorticoid-induced tumor-necrosis factor receptor-related (GITR) protein. The forced expression of Foxp3 also delays disease in CTLA-4[SUP-/-] mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T[SUBR] cell lineage.
- Publication
Nature Immunology, 2003, Vol 4, Issue 4, p337
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni909