We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
- Authors
Iwakoshi, Neal N; Lee, Ann-Hwee; Vallabhajosyula, Prasanth; Otipoby, Kevin L; Rajewsky, Klaus; Glimcher, Laurie H
- Abstract
The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, providing an integral link between XBP-1, the UPR and plasma cell differentiation. Signals involved in plasma cell differentiation, specifically interleukin-4, control the transcription of XBP-1, whereas its post-transcriptional processing is dependent on synthesis of immunoglobulins during B cell differentiation. We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR.
- Publication
Nature immunology, 2003, Vol 4, Issue 4, p321
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni907