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- Title
Foxp3 programs the development and function of CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells.
- Authors
Fontenot, Jason D.; Gavin, Marc A.; Rudensky, Alexander Y.
- Abstract
CD4[SUP+]CD25[SUP+] regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4[SUP+]CD25[SUP+] regulatory T cells and is required for their development. The lethal autoimmune syndrome observed in Foxp3-mutant scurfy mice and Foxp3-null mice results from a CD4[SUP+]CD25[SUP+] regulatory T cell deficiency and not from a cell-intrinsic defect of CD4[SUP+]CD25-T cells. CD4[SUP+]CD25[SUP+] regulatory T cells rescue disease development and preferentially expand when transferred into neonatal Foxp3deficient mice. Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4[SUP+]CD25-T cells. Thus, Foxp3 is a critical regulator of CD4[SUP+]CD25[SUP+] regulatory T cell development and function.
- Publication
Nature Immunology, 2003, Vol 4, Issue 4, p330
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni904