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- Title
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.
- Authors
Saijo, Kaoru; Schmedt, Christian; Su, I-Hsin; Karasuyama, Hajime; Lowell, Clifford A; Reth, Michael; Adachi, Takahiro; Patke, Alina; Santana, Angela; Tarakhovsky, Alexander
- Abstract
The nature of signals that govern the development of immunoglobulin heavy chain-dependent B cells is largely unknown. Using mice deficient for the B cell-expressed Src-family protein tyrosine kinases (SFKs) Blk, Fyn and Lyn, we show an essential role of these kinases in pre-B cell receptor (pre-BCR)- mediated NF-kappaB activation and B cell development. This signaling defect is SFK specific, as a deficiency in Syk, which controls pre-B cell development, does not affect NF-kappaB induction. Impaired NF-kappaB induction was overcome by the activation of protein kinase C (PKC)-lambda, thus suggesting the involvement of PKC-lambda in pre-BCR-mediated SFK-dependent activation of NF-kappaB. Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR-mediated NF-kappaB activation and B cell development.
- Publication
Nature immunology, 2003, Vol 4, Issue 3, p274
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni893