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- Title
IL-28, IL-29 and their class II cytokine receptor IL-28R.
- Authors
Sheppard, Paul; Kindsvogel, Wayne; Xu, Wenfeng; Henderson, Katherine; Schlutsmeyer, Stacy; Whitmore, Theodore E; Kuestner, Rolf; Garrigues, Ursula; Birks, Carl; Roraback, Jenny; Ostrander, Craig; Dong, Dennis; Shin, Jinu; Presnell, Scott; Fox, Brian; Haldeman, Betty; Cooper, Emily; Taft, David; Gilbert, Teresa; Grant, Francis J; Tackett, Monica; Krivan, William; McKnight, Gary; Clegg, Chris; Foster, Don; Klucher, Kevin M
- Abstract
Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.
- Publication
Nature immunology, 2003, Vol 4, Issue 1, p63
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni873