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- Title
Dominant transplantation tolerance impairs CD8<sup>+</sup> T cell function but not expansion.
- Authors
Lin, Chun-Yen; Graca, Luis; Cobbold, Stephen P.; Waldmann, Herman
- Abstract
AIIoreactive CD8[sup +] T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4[sup +] T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8[sup +] T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4[sup +] T cell "help": they proliferated and accumulated normally. However, they did show compromised graft rejection, interferon-γ production and cell-mediated cytotoxicity. These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responses.
- Publication
Nature Immunology, 2002, Vol 3, Issue 12, p1208
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni853