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- Title
Tolerization of dendritic cells by T<sub>S</sub> cells: the crucial role of inhibitory receptors ILT3 and ILT4.
- Authors
Chang, C. C.; Ciubotariu, R; Manavalan, J. S.; Yuan, J.; Colovai, A. I.; Piazza, F.; Lederman, S.; Colonna, M.; Cortesini, R.; Dalla-Favera, R.; Suciu-Foca, N.
- Abstract
Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28- alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating TS cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.
- Publication
Nature Immunology, 2002, Vol 3, Issue 3, p237
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni760