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- Title
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
- Authors
McIntire, J J; Umetsu, S E; Akbari, O; Potter, M; Kuchroo, V K; Barsh, G S; Freeman, G J; Umetsu, D T; DeKruyff, R H
- Abstract
To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-35, we examined congenic mice that differed at the homologous chromosomal segment. We identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning identified a gene family that encodes T cell membrane proteins (TIMs); major sequence variants of this gene family (Tim) completely cosegregated with Tapr. The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy.
- Publication
Nature immunology, 2001, Vol 2, Issue 12, p1109
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni739