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- Title
Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering.
- Authors
Mueller, Philipp; Massner, Jan; Jayachandran, Rajesh; Combaluzier, Benoit; Albrecht, Imke; Gatfield, John; Blum, Carmen; Ceredig, Rod; Rodewald, Hans-Reimer; Rolink, Antonius G; Pieters, Jean
- Abstract
T cell homeostasis is essential for the functioning of the vertebrate immune system, but the intracellular signals required for T cell homeostasis are largely unknown. We here report that the WD-repeat protein family member coronin-1, encoded by the gene Coro1a, is essential in the mouse for T cell survival through its promotion of Ca2+ mobilization from intracellular stores. Upon T cell receptor triggering, coronin-1 was essential for the generation of inositol-1,4,5-trisphosphate from phosphatidylinositol-4,5-bisphosphate. The absence of coronin-1, although it did not affect T cell development, resulted in a profound defect in Ca2+ mobilization, interleukin-2 production, T cell proliferation and T cell survival. We conclude that coronin-1, through activation of Ca2+ release from intracellular stores, is an essential regulator of peripheral lymphocyte survival.
- Publication
Nature immunology, 2008, Vol 9, Issue 4, p424
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni1570