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- Title
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.
- Authors
Ramalingam, Thirumalai R; Pesce, John T; Sheikh, Faruk; Cheever, Allen W; Mentink-Kane, Margaret M; Wilson, Mark S; Stevens, Sean; Valenzuela, David M; Murphy, Andrew J; Yancopoulos, George D; Urban, Joseph F, Jr; Donnelly, Raymond P; Wynn, Thomas A
- Abstract
The interleukin 4 receptor (IL-4R) is a central mediator of T helper type 2 (T(H)2)-mediated disease and associates with either the common gamma-chain to form the type I IL-4R or with the IL-13R alpha1 chain (IL-13Ralpha1) to form the type II IL-4R. Here we used Il13ra1-/- mice to characterize the distinct functions of type I and type II IL-4 receptors in vivo. In contrast to Il4ra-/- mice, which have weak T(H)2 responses, Il13ra1-/- mice had exacerbated T(H)2 responses. Il13ra1-/- mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis. IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation. Thus, type I and II IL-4 receptors exert distinct effects on immune responses.
- Publication
Nature immunology, 2008, Vol 9, Issue 1, p25
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni1544