We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.
- Authors
Stumhofer, Jason S; Silver, Jonathan S; Laurence, Arian; Porrett, Paige M; Harris, Tajie H; Turka, Laurence A; Ernst, Matthias; Saris, Christiaan J M; O'Shea, John J; Hunter, Christopher A
- Abstract
Interleukin 10 (IL-10) has a prominent function in regulating the balance between protective and pathological T cell responses. Consistent with that activity, many sources of this cytokine are found in vivo, including from myeloid cells and a variety of T cell subsets. However, although there are many pathways that regulate innate production of IL-10, the factors that govern its synthesis by the adaptive response are poorly understood. Here we report that IL-27 and IL-6 induced T helper type 1 and type 2 cells, as well as T helper cells that produce IL-17, to secrete IL-10. This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory responses.
- Publication
Nature immunology, 2007, Vol 8, Issue 12, p1363
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni1537