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- Title
The development of inflammatory T<sub>H</sub>-17 cells requires interferon-regulatory factor 4.
- Authors
Brüstle, Anne; Heink, Sylvia; Huber, Magdalena; Rosenplänter, Christine; Stadelmann, Christine; Yu, Philipp; Arpaia, Enrico; Mak, Tak W; Kamradt, Thomas; Lohoff, Michael
- Abstract
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17–producing T helper cells (TH-17 cells), which are associated with experimental autoimmune encephalomyelitis. IRF4-deficient (Irf4−/−) mice did not develop experimental autoimmune encephalomyelitis, and T helper cells from such mice failed to differentiate into TH-17 cells. Transfer of wild-type T helper cells into Irf4−/− mice rendered the mice susceptible to experimental autoimmune encephalomyelitis. Irf4−/− T helper cells had less expression of RORγt and more expression of Foxp3, transcription factors important for the differentiation of TH-17 and regulatory T cells, respectively. Altered regulation of both transcription factors contributed to the phenotype of Irf4−/− T helper cells. Our data position IRF4 at the center of T helper cell development, influencing not only T helper type 2 but also TH-17 differentiation.
- Publication
Nature Immunology, 2007, Vol 8, Issue 9, p958
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1500