We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
- Authors
LeibundGut-Landmann, Salomé; Gross, Olaf; Robinson, Matthew J; Osorio, Fabiola; Slack, Emma C; Tsoni, S Vicky; Schweighoffer, Edina; Tybulewicz, Victor; Brown, Gordon D; Ruland, Jürgen; Reis e Sousa, Caetano
- Abstract
The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs). However, whether this pathway promotes full DC activation remains unclear. Here we show that dectin-1-Syk-CARD9 signaling induced DC maturation and the secretion of proinflammatory cytokines, including IL-6, tumor necrosis factor and IL-23, but little IL-12. Dectin-1-activated DCs 'instructed' the differentiation of CD4+ IL-17-producing effector T cells (T(H)-17 cells) in vitro, and a dectin-1 agonist acted as an adjuvant promoting the differentiation of T(H)-17 and T helper type 1 cells in vivo. Infection with Candida albicans induced CARD9-dependent T(H)-17 responses to the organism. Our data indicate that signaling through Syk and CARD9 can couple innate to adaptive immunity independently of Toll-like receptor signals and that CARD9 is required for the development of T(H)-17 responses to some pathogens.
- Publication
Nature immunology, 2007, Vol 8, Issue 6, p630
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1460