We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes.
- Authors
Felix, Nathan J; Donermeyer, David L; Horvath, Stephen; Walters, James J; Gross, Michael L; Suri, Anish; Allen, Paul M
- Abstract
The molecular basis underlying the specificity of alloreactive T cells for peptide-major histocompatibility complex ligands has been elusive. Here we describe a screen of 60 I-E(k)-alloreactive T cells and 83 naturally processed peptides that identified 9 reactive T cells. Three of the T cells responded to multiple, distinct peptides that shared no sequence homology. These T cells recognized each peptide-major histocompatibility complex ligand specifically and used a distinct constellation of I-E(k) contact residues for each interaction. Our studies show that alloreactive T cells have a 'germline-encoded' capacity to recognize multiple, distinct ligands and thus show 'polyspecificity', not degeneracy. Our findings help to explain the high frequency of alloreactive T cells and provide insight into the nature of T cell specificity.
- Publication
Nature immunology, 2007, Vol 8, Issue 4, p388
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1446