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- Title
Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self.
- Authors
Lee, Je-Wook; Epardaud, Mathieu; Sun, Jing; Becker, Jessica E; Cheng, Alexander C; Yonekura, Ai-ris; Heath, Joan K; Turley, Shannon J
- Abstract
The intestinal epithelium functions to absorb nutrients and to protect the organism against microbes. To prevent autoimmune attack on this vital tissue, T cell tolerance to intestinal self-antigens must be established. Central tolerance mechanisms involve medullary thymic epithelial cells (mTECs), which use endogenously expressed peripheral-tissue antigens (PTAs) to delete self-reactive thymocytes. The prevailing model for the induction of peripheral tolerance involves cross-presentation of tissue antigens by quiescent dendritic cells. Here we show that lymph node stromal cells present endogenously expressed PTAs to T cells. Moreover, antigen presentation by lymph node stroma is sufficient to induce primary activation and subsequent tolerance among CD8(+) T cells. Thus, lymph node stromal cells are functionally akin to mTECs and provide a direct strategy for purging the peripheral repertoire of self-reactive T cells.
- Publication
Nature immunology, 2007, Vol 8, Issue 2, p181
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1427