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- Title
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.
- Authors
Hsu, Yen-Michael S; Zhang, Yongliang; You, Yun; Wang, Donghai; Li, Hongxiu; Duramad, Omar; Qin, Xiao-Feng; Dong, Chen; Lin, Xin
- Abstract
The caspase-recruitment domain-containing adaptor protein CARD9 regulates the innate signaling responses to fungal infection. Here we show that CARD9 is required for innate immune responses against intracellular pathogens. We generated Card9(-/-) mice and found that CARD9-deficient macrophages had defects in activation of the kinases p38 and Jnk but not of transcription factor NF-kappaB after bacterial and viral infection. CARD9-deficient mice failed to clear infection and showed altered cytokine production after challenge with Listeria monocytogenes. In wild-type cells, we found CARD9 inducibly associated with both the intracellular 'biosensor' Nod2 and the serine-threonine kinase RICK. Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens.
- Publication
Nature immunology, 2007, Vol 8, Issue 2, p198
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1426