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- Title
B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities.
- Authors
Li, Jun; Barreda, Daniel R; Zhang, Yong-An; Boshra, Hani; Gelman, Andrew E; Lapatra, Scott; Tort, Lluis; Sunyer, J Oriol
- Abstract
The present paradigm dictates that phagocytosis is accomplished mainly by 'professional' phagocytes (such as macrophages and monocytes), whereas B cells lack phagocytic capabilities. Here we demonstrate that B cells from teleost fish have potent in vitro and in vivo phagocytic activities. Particle uptake by B cells induced activation of 'downstream' degradative pathways, leading to 'phagolysosome' formation and intracellular killing of ingested microbes. Those results indicate a previously unknown function for B cells in the innate immunity of these primitive animals. A considerable proportion of Xenopus laevis B cells were also phagocytic. Our findings support the idea that B cells evolved from an ancestral phagocytic cell type and provide an evolutionary framework for understanding the close relationship between mammalian B lymphocytes and macrophages.
- Publication
Nature immunology, 2006, Vol 7, Issue 10, p1116
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1389