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- Title
Selection of the cutaneous intraepithelial γδ<sup>+</sup> T cell repertoire by a thymic stromal determinant.
- Authors
Lewis, Julia M.; Girardi, Michael; Roberts, Scott J.; Barbee, Susannah D.; Hayday, Adrian C.; Tigelaar, Robert E.
- Abstract
Intraepithelial lymphocytes constitute a group of T cells that express mainly monospecific or oligoclonal T cell receptors (TCRs). Like adaptive TCRαβ+ T cells, intraepithelial lymphocytes, a subset enriched in TCRγδ+ T cells, are proposed to be positively selected by thymically expressed self agonists, yet no direct evidence for this exists at present. Mouse dendritic epidermal T cells are prototypic intraepithelial lymphocytes, displaying an almost monoclonal TCRγδ+ repertoire. Here we describe an FVB substrain of mice in which this repertoire was uniquely depleted, resulting in cutaneous pathology. This phenotype was due to failure of dendritic epidermal T cell progenitors to mature because of a heritable defect in a dominant gene used by the thymic stroma to 'educate' the natural, skin-associated intraepithelial lymphocyte repertoire to be of physiological use.
- Publication
Nature Immunology, 2006, Vol 7, Issue 8, p843
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1363