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- Title
Regulation of T cell development by the deubiquitinating enzyme CYLD.
- Authors
Reiley, William W; Zhang, Minying; Jin, Wei; Losiewicz, Mandy; Donohue, Keri B; Norbury, Christopher C; Sun, Shao-Cong
- Abstract
T cell receptor signaling is essential for the generation and maturation of T lymphocyte precursors. Here we identify the deubiquitinating enzyme CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes. CYLD physically interacted with active Lck and promoted recruitment of active Lck to its substrate, Zap70. CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck. Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells.
- Publication
Nature immunology, 2006, Vol 7, Issue 4, p411
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1315