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- Title
Interleukin 17–producing CD4<sup>+</sup> effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
- Authors
Harrington, Laurie E.; Hatton, Robin D.; Mangan, Paul R.; Turner, Henrietta; Murphy, Theresa L.; Murphy, Kenneth M.; Weaver, Casey T.
- Abstract
CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (TH1) or TH2 lineages and instead favor the idea of a distinct effector lineage we call 'TH-17'. The development of TH-17 cells from naive precursor cells was potently inhibited by interferon-γ (IFN-γ) and IL-4, whereas committed TH-17 cells were resistant to suppression by TH1 or TH2 cytokines. In the absence of IFN-γ and IL-4, IL-23 induced naive precursor cells to differentiate into TH-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
- Publication
Nature Immunology, 2005, Vol 6, Issue 11, p1123
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1254