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- Title
A critical function for type I interferons in cancer immunoediting.
- Authors
Dunn, Gavin P; Bruce, Allen T; Sheehan, Kathleen C F; Shankaran, Vijay; Uppaluri, Ravindra; Bui, Jack D; Diamond, Mark S; Koebel, Catherine M; Arthur, Cora; White, J Michael; Schreiber, Robert D
- Abstract
'Cancer immunoediting' is a process wherein the immune system protects hosts against tumor development and facilitates outgrowth of tumors with reduced immunogenicity. Although interferon-gamma (IFN-gamma) is known to be involved in this process, the involvement of type I interferons (IFN-alpha/beta) has not been elucidated. We now show that, like IFN-gamma, endogenously produced IFN-alpha/beta was required for the prevention of the growth of primary carcinogen-induced and transplantable tumors. Although tumor cells are important IFN-gamma targets, they are not functionally relevant sites of the actions of the type I interferons. Instead, host hematopoietic cells are critical IFN-alpha/beta targets during development of protective antitumor responses. Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma.
- Publication
Nature immunology, 2005, Vol 6, Issue 7, p722
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1213