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- Title
Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1.
- Authors
Rossi, Fabio M V; Corbel, Stephane Y; Merzaban, Jasmeen S; Carlow, Douglas A; Gossens, Klaus; Duenas, Jeffrey; So, Leslie; Yi, Lin; Ziltener, Hermann J
- Abstract
The molecular mechanisms that direct the migration of early T lymphocyte progenitors to the thymus are unknown. We show here that P-selectin is expressed by thymic endothelium and that lymphoid progenitors in bone marrow and thymus bind P-selectin. Parabiosis, competitive thymus reconstitution and short-term homing assays indicated that P-selectin and its ligand PSGL-1 are functionally important components of the thymic homing process. Accordingly, thymi of mice lacking PSGL-1 contained fewer early thymic progenitors and had increased empty niches for prothymocytes compared with wild-type mice. Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access.
- Publication
Nature immunology, 2005, Vol 6, Issue 6, p626
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1203