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- Title
Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8<sup>+</sup> T cells.
- Authors
Binder, Robert J; Srivastava, Pramod K
- Abstract
The form in which antigens are transferred from cancer cells or infected cells to antigen-presenting cells as a part of the process of priming CD8+ T cells has been a longstanding unresolved issue. Intact proteins or protein fragments in the form of free peptides or peptides chaperoned by heat-shock protein are possible sources of antigen. We address this here usingß-galactosidase and ovalbumin. Immunization with cell lysates containing intact proteins and heat-shock protein-peptide complexes or with cell lysates depleted of either component demonstrated that protein fragments chaperoned by heat-shock protein and not intact protein were the necessary and sufficient source of antigen transferred to antigen-presenting cells for priming CD8+ T cell responses.
- Publication
Nature Immunology, 2005, Vol 6, Issue 6, p593
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1201