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- Title
Naturally arising Foxp3-expressing CD25<sup>+</sup>CD4<sup>+</sup> regulatory T cells in immunological tolerance to self and non-self.
- Authors
Sakaguchi, Shimon
- Abstract
Naturally arising CD25+CD4+ regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish transplantation tolerance. They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.
- Publication
Nature Immunology, 2005, Vol 6, Issue 4, p345
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1178