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- Title
Visualizing dendritic cell networks in vivo.
- Authors
Lindquist, Randall L; Shakhar, Guy; Dudziak, Diana; Wardemann, Hedda; Eisenreich, Thomas; Dustin, Michael L; Nussenzweig, Michel C
- Abstract
In the steady state, dendritic cells (DCs) in the lymph node induce T cell tolerance to self antigens. Innate signals trigger the maturation of tissue DCs, which migrate into lymph nodes and activate T cells. To examine DCs in vivo, we produced transgenic mice whose DCs expressed enhanced yellow fluorescent protein. Two-photon microscopy of lymph nodes in live mice showed that most of the steady-state DCs were enmeshed in an extensive network and remained in place while actively probing adjacent T cells with their processes. Mature DCs were more motile than steady-state DCs and were rapidly dispersed and integrated into the sessile network, facilitating their interaction with migrating T cells.
- Publication
Nature immunology, 2004, Vol 5, Issue 12, p1243
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1139