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- Title
Cognate CD4<sup>+</sup> T cell licensing of dendritic cells in CD8<sup>+</sup> T cell immunity.
- Authors
Smith, Christopher M.; Wilson, Nicholas S.; Waithman, Jason; Villadangos, Jose A.; Carbone, Francis R.; Heath, William R.; Belz, Gabrielle T.
- Abstract
Several studies have indicated that CD8+ T cells require CD4+ T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4+ T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4+ T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing.
- Publication
Nature Immunology, 2004, Vol 5, Issue 11, p1143
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1129