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- Title
Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.
- Authors
Bischoff, Vincent; Vignal, Cécile; Boneca, Ivo G; Michel, Tatiana; Hoffmann, Jules A; Royet, Julien
- Abstract
The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.
- Publication
Nature immunology, 2004, Vol 5, Issue 11, p1175
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1123