We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
RabGEF1 is a negative regulator of mast cell activation and skin inflammation.
- Authors
See-Ying Tam; Tsai, Mindy; Snouwaert, John N.; Kalesnikoff, Janet; Scherrer, Didier; Nakae, Susumu; Chatterjea, Devavani; Bouley, Donna M.; Galli, Stephen J.
- Abstract
Mast cell activation induced by aggregation of FceRI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways in FceRI-dependent mast cell activation. RabGEF1-deficient mast cells showed enhanced degranulation and release of lipid mediators and cytokines in response to FceRI aggregation. RabGEF1-deficient mice developed severe skin inflammation and had increased numbers of mast cells. Thus, RabGEF1 is a negative regulator of FceRI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo.
- Publication
Nature Immunology, 2004, Vol 5, Issue 8, p844
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1093