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- Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
- Authors
Yoneyama, Mitsutoshi; Kikuchi, Mika; Natsukawa, Takashi; Shinobu, Noriaki; Imaizumi, Tadaatsu; Miyagishi, Makoto; Taira, Kazunari; Akira, Shizuo; Fujita, Takashi
- Abstract
Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling, as assessed by functional screening and assays. A helicase domain with intact ATPase activity was responsible for the dsRNA-mediated signaling. The caspase recruitment domain transmitted 'downstream' signals, resulting in the activation of transcription factors NF-kappaB and IRF-3. Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes.
- Publication
Nature immunology, 2004, Vol 5, Issue 7, p730
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1087