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- Title
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.
- Authors
Dillon, Stacey R; Sprecher, Cindy; Hammond, Angela; Bilsborough, Janine; Rosenfeld-Franklin, Maryland; Presnell, Scott R; Haugen, Harald S; Maurer, Mark; Harder, Brandon; Johnston, Janet; Bort, Susan; Mudri, Sherri; Kuijper, Joseph L; Bukowski, Tom; Shea, Pamela; Dong, Dennis L; Dasovich, Maria; Grant, Francis J; Lockwood, Luann; Levin, Steven D; LeCiel, Cosette; Waggie, Kim; Day, Heather; Topouzis, Stavros; Kramer, Janet; Kuestner, Rolf; Chen, Zhi; Foster, Don; Parrish-Novak, Julia; Gross, Jane A
- Abstract
T cell-derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleukin 31 (IL-31), which is preferentially produced by T helper type 2 cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. Expression of IL-31 receptor A and oncostatin M receptor mRNA was induced in activated monocytes, whereas epithelial cells expressed both mRNAs constitutively. Transgenic mice overexpressing IL-31 developed severe pruritus, alopecia and skin lesions. Furthermore, IL-31 receptor expression was increased in diseased tissues derived from an animal model of airway hypersensitivity. These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases.
- Publication
Nature immunology, 2004, Vol 5, Issue 7, p752
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/ni1084