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- Title
Deletion of ß-catenin impairs T cell development.
- Authors
Youyuan Xu, Rafi; Banerjee, Daliya; Huelsken, Joerg; Birchmeier, Walter; Sen, Jyoti Misra
- Abstract
T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the aß TCR. Here we show that T cell-specific deletion of ß-catenin impaired T cell development at the ß-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, ß-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that ß-catenin-mediated signals are required for normal T cell development.
- Publication
Nature Immunology, 2003, Vol 4, Issue 12, p1177
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni1008