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- Title
The molecular basis of TCR germline bias for MHC is surprisingly simple.
- Authors
Christopher Garcia, K; Adams, Jarrett J; Feng, Dan; Ely, Lauren K
- Abstract
The elusive etiology of germline bias of the T cell receptor (TCR) for major histocompatibility complex (MHC) has been clarified by recent 'proof-of-concept' structural results demonstrating the conservation of specific TCR-MHC interfacial contacts in complexes bearing common variable segments and MHC allotypes. We suggest that each TCR variable-region gene product engages each type of MHC through a 'menu' of structurally coded recognition motifs that have arisen through coevolution. The requirement for MHC-restricted T cell recognition during thymic selection and peripheral surveillance has necessitated the existence of such a coded recognition system. Given these findings, a reconsideration of the TCR–peptide-MHC structural database shows that not only have the answers been there all along but also they were predictable by the first principles of physical chemistry.
- Publication
Nature Immunology, 2009, Vol 10, Issue 2, p143
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.f.219