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- Title
IL-7 signaling must be intermittent, not continuous, during CD8<sup>+</sup> T cell homeostasis to promote cell survival instead of cell death.
- Authors
Kimura, Motoko Y; Pobezinsky, Leonid A; Guinter, Terry I; Thomas, Julien; Adams, Anthony; Park, Jung-Hyun; Tai, Xuguang; Singer, Alfred
- Abstract
The maintenance of naive CD8+ T cells is necessary for lifelong immunocompetence but for unknown reasons requires signaling via both interleukin 7 (IL-7) and the T cell antigen receptor (TCR). We now report that naive CD8+ T cells required IL-7 signaling to be intermittent, not continuous, because prolonged IL-7 signaling induced naive CD8+ T cells to proliferate, produce interferon-? (IFN-?) and undergo IFN-?-triggered cell death. Homeostatic engagement of the TCR interrupted IL-7 signaling and thereby supported the survival and quiescence of CD8+ T cells. However, CD8+ T cells with insufficient TCR affinity for self ligands received prolonged IL-7 signaling and died during homeostasis. In this study we identified regulation of the duration of IL-7 signaling by homeostatic engagement of the TCR as the basis for in vivo CD8+ T cell homeostasis.
- Publication
Nature Immunology, 2013, Vol 14, Issue 2, p143
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.2494