We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
- Authors
Takahashi, Hayato; Kanno, Tomohiko; Nakayamada, Shingo; Hirahara, Kiyoshi; Sciumè, Giuseppe; Muljo, Stefan A; Kuchen, Stefan; Casellas, Rafael; Wei, Lai; Kanno, Yuka; O'Shea, John J
- Abstract
Distinct CD4(+) T cell subsets are critical for host defense and immunoregulation. Although these subsets can act as terminally differentiated lineages, they have been increasingly noted to demonstrated plasticity. MicroRNAs are factors that control T cell stability and plasticity. Here we report that naturally occurring regulatory T cells (T(reg) cells) had high expression of the microRNA miR-10a and that miR-10a was induced by retinoic acid and transforming growth factor-β (TGF-β) in inducible T(reg) cells. By simultaneously targeting the transcriptional repressor Bcl-6 and the corepressor Ncor2, miR-10a attenuated the phenotypic conversion of inducible T(reg) cells into follicular helper T cells. We also found that miR-10a limited differentiation into the T(H)17 subset of helper T cells and therefore represents a factor that can fine-tune the plasticity and fate of helper T cells.
- Publication
Nature immunology, 2012, Vol 13, Issue 6, p587
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.2286