We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes.
- Authors
Narayan, Kavitha; Sylvia, Katelyn E; Malhotra, Nidhi; Yin, Catherine C; Martens, Gregory; Vallerskog, Therese; Kornfeld, Hardy; Xiong, Na; Cohen, Nadia R; Brenner, Michael B; Berg, Leslie J; Kang, Joonsoo; Immunological Genome Project Consortium
- Abstract
Innate γδ T cells function in the early phase of immune responses. Although innate γδ T cells have often been studied as one homogenous population, they can be functionally classified into effector subsets on the basis of the production of signature cytokines, analogous to adaptive helper T cell subsets. However, unlike the function of adaptive T cells, γδ effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains, which suggests that clonal TCR selection is not the main determinant of the differentiation of γδ effector cells. A high-resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated on the basis of use of the TCR γ-chain or δ-chain indicated the existence of three separate subtypes of γδ effector cells in the thymus. The immature γδ subsets were distinguished by unique transcription-factor modules that program effector function.
- Publication
Nature immunology, 2012, Vol 13, Issue 5, p511
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.2247